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瀝青基球狀活性炭的醫用性能評價

注意:本論文已在《新型炭材料》2002,17(3):11-14發表
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瀝青基球狀活性炭的醫用性能評價
呂春祥1 ,  李開喜1 ,  呂永根1 ,  梁曉懌1 ,  宋 燕1 ,凌立成1 ,  王占仁2 ,  國建琴2
(1. 中國科學院山西煤炭化學研究所, 山西太原 030001 ;  2. 廊坊愛爾血液凈化器材廠, 河北廊坊 065000)

摘要:表征了瀝青基球狀活性炭的基本結構參數(如比表面積、孔容量、球形度、強度、重金屬含量等) ,測定了 其對血液中典型中、小毒性分子的吸附性能(肌酐和VB12 ) 和溶血反應率,分析了以瀝青基球狀活性炭為吸附劑的 人工炭腎的微粒釋放量、熱源和細菌含量,并進行臨床試驗。結果表明:瀝青基球狀活性炭球形度好,強度高,具有 良好的廣譜吸附性能,對血液中典型的中、小毒性分子吸附能力強,重金屬含量低,溶血率低,微粒釋放量少,無熱 源、無菌,血液灌流臨床試驗效果滿意,可以作為人工炭腎的吸附劑。
關鍵詞:瀝青基球狀活性炭; 吸附; 溶血反應; VB12 ; 肌酐
文章編號:  100728827(2002) 0320011204

THE MEDICAL PERFORMANCE OF PITCH2BASED SPHERICAL ACTIVATED CARBON

LU Chun-xiang1 ,  LI Kai-xi1 ,  LU Yong-gen1 ,  LIANG Xiao-yi1 ,  SONG Yan1 , LING Li-cheng1 ,  WANG Zhan-ren2 ,  GUO Jian-qin2
(1. Institute of Coal Chemistry , Chinese Academy of Sciences , Taiyuan  030001 , China ; 2. Aier Blood Purification Apparatus Factory , Langfang  065000 , China)


Abstract
: The basic structural parameters of pitch2based spherical activated carbon (PSAC) were characterized ,such as specific surface area by BET model , total pore volume , micropore and mesopore volume , sphericity , hardness and content of heavy metal ions . Its adsorption capacity to creatinine and vitamin B 12 , which are typical small and medium toxic molecules in blood , were measured. Hemolysis ratio , number of particles released , pyrexic source and germ count in a man2made kidney made of PSAC were checked . The results showed that PSAC had many excellent properties such as high hardness , large adsorption range , good adsorbing ability to typical toxic molecules in blood ,low content of heavy metalions , low hemolysis ratio , few released particles and no pyrexic source and germs . Satisfactory results have been obtained in clinical experiments for blood purification , which show that PSAC can be used as an adsorbent for a man-made kidney.
Key words : itch-based spherical activated carbon ; Adsorption ; Homolysis ; Vitamin B12 ; Creatinine

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